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fda999u fda999w  (Novus Biologicals)


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    Novus Biologicals fda999u fda999w
    Fda999u Fda999w, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 23 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+prostate+tissues/Human+Prostate+Tissue+MicroArray+(Cancer)/pmc12767472-518-6-13
    Average 90 stars, based on 23 article reviews
    fda999u fda999w - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    Staining:

    Article Title: Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens.
    Article Snippet: .. Staining of metastatic colon cancer under the same conditions is shown as a positive control. (B–E) Normal human TMAs (FDA999w from BioMAx, B and C and FDA999-1 from US Biolabs, D and E), each containing 32 different tissues with replicates from 3 different individuals, along with a prostate cancer microarray (NBP2-30169 from Novus Biologicals) were stained with/without GlyTR1 with detection by anti6xHis-HRP antibody. ..

    Positive Control:

    Article Title: Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens.
    Article Snippet: .. Staining of metastatic colon cancer under the same conditions is shown as a positive control. (B–E) Normal human TMAs (FDA999w from BioMAx, B and C and FDA999-1 from US Biolabs, D and E), each containing 32 different tissues with replicates from 3 different individuals, along with a prostate cancer microarray (NBP2-30169 from Novus Biologicals) were stained with/without GlyTR1 with detection by anti6xHis-HRP antibody. ..

    Microarray:

    Article Title: Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens.
    Article Snippet: .. Staining of metastatic colon cancer under the same conditions is shown as a positive control. (B–E) Normal human TMAs (FDA999w from BioMAx, B and C and FDA999-1 from US Biolabs, D and E), each containing 32 different tissues with replicates from 3 different individuals, along with a prostate cancer microarray (NBP2-30169 from Novus Biologicals) were stained with/without GlyTR1 with detection by anti6xHis-HRP antibody. ..

    Article Title: Overexpression of Exportin-5 Overrides the Inhibitory Effect of miRNAs Regulation Control and Stabilize Proteins via Posttranslation Modifications in Prostate Cancer
    Article Snippet: Cells were resuspended in 1 × PBS (PH 7.4; BioSource, Rockville, MD) mixed 1 × with Matrigel (BD .. Prostate cancer tissue microarray TMA (IMH-303) was obtained from IMGENEX (San Diego, CA) which contains 49 formalin fixed paraffin embedded (FFPE) 4.0 mm prostatectomy cores. ..

    Article Title: Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis.
    Article Snippet: .. Human prostate cancer tissue microarray (TMA) was purchased from Novus (NBP2-30169, Saint Charles, MO, USA). ..

    Article Title: Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis
    Article Snippet: .. Histopathology Human prostate cancer tissue microarray (TMA) was purchased from Novus (NBP2-30169, Saint Charles, MO, USA). ..

    Article Title: Prostate Field Cancerization: Deregulated Expression of Macrophage Inhibitory Cytokine 1 (MIC-1) and Platelet Derived Growth Factor A (PDGF-A) in Tumor Adjacent Tissue
    Article Snippet: .. A human prostate tissue microarray featuring 9 histologically normal tissues matched to their corresponding tumors was purchased from Novus Biologicals (catalog #NBP2–30169; San Diego CA). ..

    Formalin-fixed Paraffin-Embedded:

    Article Title: Overexpression of Exportin-5 Overrides the Inhibitory Effect of miRNAs Regulation Control and Stabilize Proteins via Posttranslation Modifications in Prostate Cancer
    Article Snippet: Cells were resuspended in 1 × PBS (PH 7.4; BioSource, Rockville, MD) mixed 1 × with Matrigel (BD .. Prostate cancer tissue microarray TMA (IMH-303) was obtained from IMGENEX (San Diego, CA) which contains 49 formalin fixed paraffin embedded (FFPE) 4.0 mm prostatectomy cores. ..

    Immunohistochemical staining:

    Article Title: LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.
    Article Snippet: .. Immunohistochemical (IHC) Analysis of Prostate Cancer Tissue Microarrays Human PCa tissue microarrays (TMAs), commercially available from Novus Biologicals and US Biomax Inc. were used for IHC analysis of LEDGF/p75 and ERp57. .. Three different PCa TMAs (two from US Biomax Inc. and one from Novus Biologicals) were used to increase the sample size.

    Immunohistochemistry:

    Article Title: LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.
    Article Snippet: .. Immunohistochemical (IHC) Analysis of Prostate Cancer Tissue Microarrays Human PCa tissue microarrays (TMAs), commercially available from Novus Biologicals and US Biomax Inc. were used for IHC analysis of LEDGF/p75 and ERp57. .. Three different PCa TMAs (two from US Biomax Inc. and one from Novus Biologicals) were used to increase the sample size.

    Histopathology:

    Article Title: Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis
    Article Snippet: .. Histopathology Human prostate cancer tissue microarray (TMA) was purchased from Novus (NBP2-30169, Saint Charles, MO, USA). ..

    other:

    Article Title: Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
    Article Snippet: Formalin-fixed paraffin-embedded sections were stained for F4/80 (eBiociences), CD-31 (Dako), and α-SMA (Sigma Aldrich) using standard procedures.



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    Image Search Results


    ( A ) Analysis of Siglec-engaging sialoglycans using HYDRA immunohistochemistry in a TMA comprising 51 prostate tissue samples shows ligands for Siglec-3 (unpaired t test, p=0.0216), Siglec-7 (unpaired t test, p=0.0143) and Siglec-9 (unpaired t test, p=0.0271) are upregulated in prostate tumour tissue relative to normal prostate tissue. ( B ) Staining a previously published 96 case TMA [ , ] containing 17 normal prostate tissue samples and 79 samples of prostate tumour tissue showed that sialoglycan ligands for Siglec-3 (unpaired t test, p<0.001), Siglec-7 (unpaired t test, p<0.0001) and Siglec-9 (unpaired t test, p0.0171) are found at significantly higher levels in prostate tumours compared to normal prostate tissues. ( C ) HYDRA immunohistochemistry analysis of Siglec-3, -7 and -9 ligands in a previously published 200 case TMA [ , ] containing matched tumour and normal tissues from the same patient. Sialoglycan ligands recognised by Siglec-3 (paired t test, p<0.0001), Siglec-7 (paired t test, p=0.0003) and Siglec-9 (p<0.0001) are significantly increased in prostate cancer tissue relative to matched normal tissue from the same patient. Scale bar is 200□µm.

    Journal: bioRxiv

    Article Title: Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis

    doi: 10.1101/2025.11.12.687981

    Figure Lengend Snippet: ( A ) Analysis of Siglec-engaging sialoglycans using HYDRA immunohistochemistry in a TMA comprising 51 prostate tissue samples shows ligands for Siglec-3 (unpaired t test, p=0.0216), Siglec-7 (unpaired t test, p=0.0143) and Siglec-9 (unpaired t test, p=0.0271) are upregulated in prostate tumour tissue relative to normal prostate tissue. ( B ) Staining a previously published 96 case TMA [ , ] containing 17 normal prostate tissue samples and 79 samples of prostate tumour tissue showed that sialoglycan ligands for Siglec-3 (unpaired t test, p<0.001), Siglec-7 (unpaired t test, p<0.0001) and Siglec-9 (unpaired t test, p0.0171) are found at significantly higher levels in prostate tumours compared to normal prostate tissues. ( C ) HYDRA immunohistochemistry analysis of Siglec-3, -7 and -9 ligands in a previously published 200 case TMA [ , ] containing matched tumour and normal tissues from the same patient. Sialoglycan ligands recognised by Siglec-3 (paired t test, p<0.0001), Siglec-7 (paired t test, p=0.0003) and Siglec-9 (p<0.0001) are significantly increased in prostate cancer tissue relative to matched normal tissue from the same patient. Scale bar is 200□µm.

    Article Snippet: TMA cohort 1 : 40 case human prostate cancer TMA was purchased from Novus Bio (NBP2-30169).

    Techniques: Immunohistochemistry, Staining

    ( A ) HYDRA immunohistochemistry analysis of ligands for Siglec-3, Siglec-7, and Siglec-9 in untreated primary prostate tissue compared to metastatic castrate resistant cancer (CRPC) growing in bone suggests all three sialoglycan ligands are increased in treatment resistant metastatic tumours relative to untreated primary prostate cancer tissues (n=205, unpaired t tests, HYDRA-3 p <0.0001, HYDRA-7 p<0.0001, HYDRA-9 p<0.0001). Scale bar is 200□µm. ( B ) Analysis of Siglec-7 ligands in a TMA generated by the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project . HYDRA-7 immunohistochemistry shows Siglec-7 ligands are expressed at similar levels in untreated / hormone naïve primary prostate tumours compared to therapy resistant (CRPC) tissues (n=161, unpaired t test, p=0.0904). Scale bar is 200□µm. ( C ) HYDRA immunohistochemistry analysis of Siglec-7 ligands in a TMA containing primary prostate tissue and rapid autopsy tissue obtained from lethal visceral and bone metastatic tumours . HYDRA-7 Histoscores were significantly higher in lethal bone metastatic prostate tumours compared to unmatched primary prostate tumours (n=238, Welsh’s ANOVA test, p<0.0001). The levels of Siglec-7 ligands were significantly higher in prostate derived tumours growing in bone compared to matched visceral tumour tissue from the same patient (n=100, paired t test, p<0.0001). Scale bar is 200□µm. ( D ) HYDRA-7 immunohistochemistry analysis of Siglec-7 ligands in a 100-case prostate cancer TMA. Stratification of patients based on high and low Siglec-7 ligand levels shows patients with high HYDRA-7 levels (defined as the top 50 th percentile of expression) had significantly poorer survival rates compared to patients with low HYDRA-7 levels (defined as the bottom 50 th percentile of expression) (n=100, Kaplan-Meier regression model, p= 0.0041). Scale bar is 200□µm.

    Journal: bioRxiv

    Article Title: Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis

    doi: 10.1101/2025.11.12.687981

    Figure Lengend Snippet: ( A ) HYDRA immunohistochemistry analysis of ligands for Siglec-3, Siglec-7, and Siglec-9 in untreated primary prostate tissue compared to metastatic castrate resistant cancer (CRPC) growing in bone suggests all three sialoglycan ligands are increased in treatment resistant metastatic tumours relative to untreated primary prostate cancer tissues (n=205, unpaired t tests, HYDRA-3 p <0.0001, HYDRA-7 p<0.0001, HYDRA-9 p<0.0001). Scale bar is 200□µm. ( B ) Analysis of Siglec-7 ligands in a TMA generated by the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project . HYDRA-7 immunohistochemistry shows Siglec-7 ligands are expressed at similar levels in untreated / hormone naïve primary prostate tumours compared to therapy resistant (CRPC) tissues (n=161, unpaired t test, p=0.0904). Scale bar is 200□µm. ( C ) HYDRA immunohistochemistry analysis of Siglec-7 ligands in a TMA containing primary prostate tissue and rapid autopsy tissue obtained from lethal visceral and bone metastatic tumours . HYDRA-7 Histoscores were significantly higher in lethal bone metastatic prostate tumours compared to unmatched primary prostate tumours (n=238, Welsh’s ANOVA test, p<0.0001). The levels of Siglec-7 ligands were significantly higher in prostate derived tumours growing in bone compared to matched visceral tumour tissue from the same patient (n=100, paired t test, p<0.0001). Scale bar is 200□µm. ( D ) HYDRA-7 immunohistochemistry analysis of Siglec-7 ligands in a 100-case prostate cancer TMA. Stratification of patients based on high and low Siglec-7 ligand levels shows patients with high HYDRA-7 levels (defined as the top 50 th percentile of expression) had significantly poorer survival rates compared to patients with low HYDRA-7 levels (defined as the bottom 50 th percentile of expression) (n=100, Kaplan-Meier regression model, p= 0.0041). Scale bar is 200□µm.

    Article Snippet: TMA cohort 1 : 40 case human prostate cancer TMA was purchased from Novus Bio (NBP2-30169).

    Techniques: Immunohistochemistry, Generated, Microarray, Derivative Assay, Expressing